The primary cilium can keep cancer at bay, or it can instigate tumor development, according to studies in mice (pages 1055–1061 and 1062–1065). The outcome depends on the nature of the initiating event, which involves signaling through the Hedgehog pathway.
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Toftgård, R. Two sides to cilia in cancer. Nat Med 15, 994–996 (2009). https://doi.org/10.1038/nm0909-994
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DOI: https://doi.org/10.1038/nm0909-994
