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Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

Nature Medicine volume 8, pages 673–680 (2002)Cite this article

Abstract

Adequate control of HIV requires impairing the infection, replication and spread of the virus, no small task given the extraordinary capacity of HIV to exploit the cell's molecular machinery in the course of infection. Understanding the dynamic interplay of host cell and virus is essential to the effort to eradicate HIV.

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Figure 1
Figure 2
Figure 3
Figure 4: A summary of late events in the HIV-infected cell culminating in the assembly of new infectious virions.
Figure 5: Late steps in the assembly of new virions.

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Acknowledgements

We thank J.C.W. Carroll for graphic arts; J. Sodroski and members of our laboratories for helpful comments on the manuscript. W.C.G. thanks the Gladstone Institutes, National Institutes of Health (P01 HD40543, R01AI45234, R01 CA86814 and P30MH59037), the University-wide AIDS Research Program (C99-SF-002), and the J.B. Pendleton Trust for funding support. B.M.P. thanks the National Institutes of Health (R01AI38532, R01AI46967, R01AI49104 and R01A151165-01) and University of California University-wide AIDS Research Program (R00-SF-006) for funding support.

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  1. Gladstone Institute of Virology and Immunology University of California at San Francisco, San Francisco, California, USA

    Warner C. Greene

  2. Rosalind Russell Medical Research Center University of California at San Francisco, San Francisco, California, USA

    B. Matija Peterlin

  3. Departments of Medicine, Microbiology and Immunology University of California at San Francisco, San Francisco, California, USA

    Warner C. Greene & B. Matija Peterlin

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Greene, W., Peterlin, B. Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy. Nat Med 8, 673–680 (2002). https://doi.org/10.1038/nm0702-673

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