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Putting the heat on ALS

Nature Medicine volume 10, pages 345–347 (2004)Cite this article

An enhancer of the heat shock response alleviates symptoms of neurodegeneration and prolongs lifespan in a mouse model of amyotrophic lateral sclerosis—even when administered after onset (pages 402–405).

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Figure 1: Stressors such as heat, oxidants, toxins and mutations trigger misfolding of mutant (red) and wild-type (blue) SOD-1; this initiates trimerization of HSF-1 monomers in the cytoplasm.
Figure 2: Upregulating HSPs.

Courtesy of Linda Greensmith and Dairun Kieran

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Authors and Affiliations

  1. Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown, 02129, Massachusetts, USA

    Susanna C Benn & Robert H Brown Jr

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  1. Susanna C Benn
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  2. Robert H Brown Jr
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Benn, S., Brown, R. Putting the heat on ALS. Nat Med 10, 345–347 (2004). https://doi.org/10.1038/nm0404-345

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