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Lipid unites disparate syndromes of sepsis

Nature Medicine volume 10, pages 124–125 (2004)Cite this article

Sepsis is by no means a single clinical entity; physicians must battle a variety of syndromes with only a vague notion of the molecular events that connect them. This vagueness now begins to dissipate with the identification of a molecule that can prevent the development of acute septic shock and severe sepsis (pages 161–167).

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Figure 1: Chain of events from infection to sepsis and septic shock.

Kimberly Caesar

References

  1. Yan, J.-J. et al. Nat. Med. 10, 161–167 (2004).

    Article  CAS  Google Scholar 

  2. Hotchkiss, R.S. & Karl, I.E. N. Engl. J. Med. 348, 138–150 (2003).

    Article  CAS  Google Scholar 

  3. Tracey, K.J. et al. Science 234, 470–474 (1986).

    Article  CAS  Google Scholar 

  4. Tracey, K.J. et al. Nature 330, 662–664 (1987).

    Article  CAS  Google Scholar 

  5. Eskandari, M.K. et al. J. Immunol. 148, 2724–2730 (1992).

    CAS  PubMed  Google Scholar 

  6. Wang, H. et al. Science 285, 248–251 (1999).

    Article  CAS  Google Scholar 

  7. Yang, H. et al. Proc. Natl. Acad. Sci. USA 101, 296–301 (2004).

    Article  CAS  Google Scholar 

  8. Wang, H., Yang, H., Czura, C.J., Sama, A.E. & Tracey, K.J. Am. J. Respir. Crit. Care Med. 164, 1768–1773 (2001).

    Article  CAS  Google Scholar 

  9. Ulloa, L. et al. Proc. Natl. Acad. Sci. USA 99, 12351–12356 (2002).

    Article  CAS  Google Scholar 

  10. Kabarowski, J.H., Zhu, K., Le, L.Q., Witte, O.N. & Xu, Y. Science 293, 702–705 (2001).

    Article  CAS  Google Scholar 

  11. Drobnik, W. et al. J. Lipid Res. 44, 754–761 (2003).

    Article  CAS  Google Scholar 

  12. Calandra, T. et al. Nat. Med 6, 164–170 (2000).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. North Shore–LIJ Research Institute, 350 Community Drive, Manhasset, New York, 11030, USA

    Haichao Wang, Christopher J Czura & Kevin J Tracey

  2. a co-founder of Critical Therapeutics Inc., which develops experimental therapies that target critical care medicine,

    Kevin J Tracey

Authors
  1. Haichao Wang
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  2. Christopher J Czura
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  3. Kevin J Tracey
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Wang, H., Czura, C. & Tracey, K. Lipid unites disparate syndromes of sepsis. Nat Med 10, 124–125 (2004). https://doi.org/10.1038/nm0204-124

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