Two recent studies provide novel insights into the mechanism of action of thalidomide analogs in multiple myeloma and del(5q) myelodysplastic syndrome. They show that the role of the chaperone function of cereblon, and a calcium- and calpain-dependent pathway, are important in anticancer functions.
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Bergsagel, P., Chesi, M. Promiscuous mechanisms underlie the antitumor effects of thalidomide analogs. Nat Med 22, 706–707 (2016). https://doi.org/10.1038/nm.4144
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DOI: https://doi.org/10.1038/nm.4144
