Metastatic colorectal cancer is a largely incurable disease with a pressing need for targeted therapies. A new study sheds light on a surprising interaction between FOXO3a and β-catenin in metastatic colorectal cancer, suggesting new therapeutic avenues for agents targeting the PI3K-AKT pathway (pages 892–901).
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Yan, Y., Lackner, M. FOXO3a and β-catenin co-localization: double trouble in colon cancer?. Nat Med 18, 854–856 (2012). https://doi.org/10.1038/nm.2799
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DOI: https://doi.org/10.1038/nm.2799
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