For both mice and humans, an invariant T cell receptor mediates the recognition of glycolipid antigens presented in the context of CD1d molecules. Crystal structure and mutagenesis-based analyses now identify a minimalist binding mode well suited to an 'innate-style' pattern-recognition function.
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Jones, E., Salio, M. & Cerundolo, V. T cell receptors get back to basics. Nat Immunol 8, 1033–1035 (2007). https://doi.org/10.1038/ni1007-1033
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DOI: https://doi.org/10.1038/ni1007-1033