The production of inflammatory interleukin 1β after uptake of silica crystals and alum salt or amyloid-β occurs by a process that involves lysosomal destabilization and release of cathepsin B that activates the NLRP3 inflammasome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hoffman, H.M., Mueller, J.L., Broide, D.H., Wanderer, A.A. & Kolodner, R.D. Nat. Genet. 29, 301–305 (2001).
Agostini, L. et al. Immunity 20, 319–325 (2004).
Hornung, V. et al. Nat. Immunol. 9, 847–856 (2008).
Halle, A. et al. Nat. Immunol. 9, 857–865 (2008).
Jones, J.D.G. & Dangl, J.L. Nature 444, 323–329 (2006).
Dostert, C. et al. Science 320, 674–677 (2008).
Cassel, S.L. et al. Proc. Natl. Acad. Sci. 105, 9035–9040 (2008).
Li, H., Willingham, S.B., Ting, J.P.Y. & Re, F. J. Immunol. 181, 17–21 (2008).
Eisenbarth, S.C. & Colegio, O.R. Nature 453, 1122–1126 (2008).
Fujisawa, A. et al. Blood 109, 2903–2911 (2007).
Willingham, S.B. et al. Cell Host Microbe 2, 147–159 (2007).
Shao, F. et al. Science 301, 1230–1233 (2003).
Kanneganti, T. et al. Immunity 26, 433–443 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Willingham, S., Ting, JY. NLRs and the dangers of pollution and aging. Nat Immunol 9, 831–833 (2008). https://doi.org/10.1038/ni0808-831
Issue Date:
DOI: https://doi.org/10.1038/ni0808-831
This article is cited by
-
Regulation of innate immune responses in the brain
Nature Reviews Immunology (2009)