AID acts to further refine the immunoglobulin response in fish, birds and mammals. Now, evidence is uncovered to suggest AID actually arose early in evolution and can diversify antigen receptors in lampreys.
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Schatz, D. DNA deaminases converge on adaptive immunity. Nat Immunol 8, 551–553 (2007). https://doi.org/10.1038/ni0607-551
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DOI: https://doi.org/10.1038/ni0607-551
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