Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Opn: key regulator of pDC interferon production

Nature Immunology volume 7, pages 441–443 (2006)Cite this article

Plasmacytoid dendritic cells selectively express Toll-like receptors 7 and 9 and respond to virus infection by triggering massive interferon production, a pathway regulated by osteopontin expressed in plasmacytoid dendritic cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: In pDCs, herpes simplex virus 1 (HSV-1) and CpG DNA trigger T-bet-mediated induction of Opn expression.

Katie Ris

References

  1. Colonna, M., Trinchieri, G. & Liu, Y.J. Nat. Immunol. 5, 1219–1226 (2004).

    Article  CAS  Google Scholar 

  2. Liu, Y.-J. Annu. Rev. Immunol. 23, 275–306 (2005).

    Article  CAS  Google Scholar 

  3. Kawai, T. & Akira, S. Nat. Immunol. 7, 131–137 (2006).

    Article  CAS  Google Scholar 

  4. Shinohara, M.L. et al. Nat. Immunol. 7, 498–506 (2006).

    Article  CAS  Google Scholar 

  5. Mazzali, M. et al. Q. J. Med. 95, 3–13 (2002).

    Article  CAS  Google Scholar 

  6. Pass, H.I. et al. N. Engl. J. Med. 353, 1564–1573 (2005).

    Article  CAS  Google Scholar 

  7. Gravallese, E.M. J. Clin. Invest. 112, 147–149 (2003).

    Article  CAS  Google Scholar 

  8. Shinohara, M.L. et al. Proc. Natl. Acad. Sci. USA 102, 17101–17106 (2005).

    Article  CAS  Google Scholar 

  9. Ashkar, S. et al. Science 287, 860–864 (2000).

    Article  CAS  Google Scholar 

  10. Zohar, R. et al. J. Cell. Physiol. 184, 118–130 (2000).

    Article  CAS  Google Scholar 

  11. Abel, B., Freigang, S., Bachmann, M.F., Boschert, U. & Kopf, M. J. Immunol. 175, 6006–6013 (2005).

    Article  CAS  Google Scholar 

  12. Chabas, D. et al. Science 294, 1731–1735 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston, 77030, Texas, USA

    Wei Cao & Yong-Jun Liu

Authors
  1. Wei Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yong-Jun Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cao, W., Liu, YJ. Opn: key regulator of pDC interferon production. Nat Immunol 7, 441–443 (2006). https://doi.org/10.1038/ni0506-441

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0506-441

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing