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Paradigm switching in the germinal center

Nature Immunology volume 5, pages 476–477 (2004)Cite this article

Antigen receptor genes are assembled by a sequence of lineage-specific recombinatorial events, in which DNA breaks must be properly repaired to ensure cell survival and further developmental maturation. B lymphocytes, it seems, use multiple unique pathways to repair their DNA.

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Figure 1: Parallels between two DNA rearrangements occurring at the Igh locus: V(D)J recombination (left) rearranges V, D and J segments to encode the variable region of the immunoglobulin molecule, whereas CSR (right) rearranges a mature immunoglobulin variable region with one of several immunoglobulin constant (C) regions.

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Authors and Affiliations

  1. Skirball Institute and Department of Pathology, Program in Molecular Pathogenesis, NYU School of Medicine, New York, 10016, New York, USA

    Jennifer E Posey, Vicky L Brandt & David B Roth

  2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, 77030, Texas, USA

    Jennifer E Posey

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  1. Jennifer E Posey
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  2. Vicky L Brandt
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  3. David B Roth
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Posey, J., Brandt, V. & Roth, D. Paradigm switching in the germinal center. Nat Immunol 5, 476–477 (2004). https://doi.org/10.1038/ni0504-476

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