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Reply to: "Subverting misconceptions about radiation therapy"

Nature Immunology volume 17, pages 345–346 (2016)Cite this article

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Price, Idoyaga and Merad reply:

A recent article from our group reported on an underlying mechanism of resistance to depletion by ionizing irradiation that is used by LCs, a unique population of dendritic cells that reside in the epidermis1. Formenti et al. raise one major objection to our report: that our mouse model system bears little resemblance to clinical radiotherapy. In our tumor-challenge experiments, we administered TBI at a dose of 6 Gy to mice that we subsequently challenged subcutaneously with B16 cells. As stated in our initial report, our goal was twofold. First, we sought to determine the effect of conditioning-radiation therapy on the local immunological milieu, independently of any direct tumoricidal effect of radiation itself on an established tumor. Second, we sought to further characterize the mechanisms by which tumors evade local control following radiation therapy. To that end, we were able to identify a novel mechanism by which radioresistant LCs promote tumor-protective Treg cells following radiation exposure.

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Author notes

  1. Juliana Idoyaga

    Present address: Present address: Department of Microbiology and Immunology, Stanford University, Stanford, California, USA.,

Authors and Affiliations

  1. Tisch Cancer Institute and Immunology Institute Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Jeremy G Price, Juliana Idoyaga & Miriam Merad

Authors
  1. Jeremy G Price
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  2. Juliana Idoyaga
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  3. Miriam Merad
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Corresponding author

Correspondence to Miriam Merad.

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The authors declare no competing financial interests.

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Price, J., Idoyaga, J. & Merad, M. Reply to: "Subverting misconceptions about radiation therapy". Nat Immunol 17, 345–346 (2016). https://doi.org/10.1038/ni.3376

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