The chemoattractant receptor GPR15 directs the homing of T cells to the colon; however, GRP15 expression differs in the effector and regulatory T cell subsets of humans versus those of mice. These findings have profound implications for the potential targeting of GRP15 for therapeutic intervention.
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J.L.V. is employed by Biogen Idec.
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Bilsborough, J., Viney, J. GPR15: a tale of two species. Nat Immunol 16, 137–139 (2015). https://doi.org/10.1038/ni.3084
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DOI: https://doi.org/10.1038/ni.3084