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NLRP3 inflammasome activation: CD36 serves double duty

Nature Immunology volume 14, pages 772–774 (2013)Cite this article

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Studies have linked the NLRP3 inflammasome pathway to the elaboration of sterile inflammation. CD36 serves a dual role by priming transcription of the gene encoding interleukin 1β (IL-1β) and inducing assembly of the NLRP3 inflammasome complex, which leads to the release of active IL-1β.

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Figure 1: The role of CD36 in activating the NLRP3 inflammasome in the absence of infection.

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Authors and Affiliations

  1. Jonathan C. Kagan is with the Department of Pediatrics, and the Division of Gastroenterology, Harvard Medical School, Boston, Massachusetts, USA, Boston Children's Hospital, Boston, Massachusetts, USA.,

    Jonathan C Kagan

  2. Tiffany Horng is in the Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.,

    Tiffany Horng

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  1. Jonathan C Kagan
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  2. Tiffany Horng
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Correspondence to Jonathan C Kagan.

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The authors declare no competing financial interests.

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Kagan, J., Horng, T. NLRP3 inflammasome activation: CD36 serves double duty. Nat Immunol 14, 772–774 (2013). https://doi.org/10.1038/ni.2668

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