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Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

Nature Genetics volume 2, pages 335–339 (1992)Cite this article

Abstract

Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the β–amyloid protein precursor gene located in 21q21.3 have indicated that early–onset Alzheimer's disease (EOAD) is a heterogeneous disorder for which at least one other chromosomal locus exists. We examined two extended histopathologically confirmed EOAD pedigrees, AD/A and AD/B, with highly informative short tandem repeat (STR) polymorphisms and found complete linkage of the disease to a (CA)n dinucleotide repeat polymorphism at locus D14S43 in 14q24.3 (Zmax = 13.25 at θ = 0.0). Using additional chromosome 14 STR polymorphisms we were able to delineate the region containing the EOAD gene to an area of, at most, 8.9 centiMorgans between D14S42 and D14S53, flanking D14S43 on both sides.

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Authors and Affiliations

  1. Laboratory of Neurogenetics, Born Bunge Foundation, University of Antwerp, Department of Biochemistry, Universiteitsplein 1, B-2610, Antwerpen, Belgium

    Christine Van Broeckhoven, Hubert Backhovens, Marc Cruts & Goedele De Winter

  2. Innogenetics Inc., Industriepark Zwijnaarde 7, Box 4, B-9052, Gent, Belgium

    Hubert Backhovens & Goedele De Winter

  3. Department of Neurology, City Hospital of Ronse, B-9600, Ronse

    Marc Bruyland

  4. Department of Neurology, University of Brussels, B-1090, Brussel, Belgium

    Marc Bruyland

  5. Laboratories of Neurobiology and Neuropathology, Born Bunge Foundation, University of Antwerp, Department of Medicine, Universiteitsplein 1, B-2610, Antwerpen, Belgium

    Patrick Cras & Jean-Jacques Martin

Authors
  1. Christine Van Broeckhoven
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Van Broeckhoven, C., Backhovens, H., Cruts, M. et al. Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3. Nat Genet 2, 335–339 (1992). https://doi.org/10.1038/ng1292-335

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