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Zinc transport and diabetes risk

Nature Genetics volume 46, pages 323–324 (2014)Cite this article

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Genome-wide association studies have previously identified variants in SLC30A8, encoding the zinc transporter ZnT8, associated with diabetes risk. A rare variant association study has now established the direction of effect, surprisingly showing that loss-of-function mutations in SLC30A8 are protective against diabetes.

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Figure 1: Model for ZnT8 and regulation of insulin and C-peptide.

Kim Caesar

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Authors and Affiliations

  1. Ewan Pearson is in the Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, UK.,

    Ewan Pearson

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  1. Ewan Pearson
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Correspondence to Ewan Pearson.

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Pearson, E. Zinc transport and diabetes risk. Nat Genet 46, 323–324 (2014). https://doi.org/10.1038/ng.2934

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