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Effect of Dimethylbenzyldesmethylrifampicin (DMB) on Chemically Induced Mammary Tumours in Rats

Nature New Biology volume 242, pages 88–90 (1973)Cite this article

Abstract

SEVERAL derivatives of rifamycin SV have been shown to inhibit virus-induced transformation in tissue culture. Transformation of chick fibroblasts induced by Rous sarcoma virus (RSV) is inhibited by rifampicin at levels of 20–60 µg/ml.1–3, and the transformation of Balb/3T3 cells induced by Moloney sarcoma virus (MSV) is inhibited more than 90% by dimethyl-benzyldesmethylrifampicin (DMB) at levels of 6 µg/ml.4,5.

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Authors and Affiliations

  1. Laboratory of Chemical Biodynamics, University of California, Berkeley, California, 94720

    URS R. JOSS, ANN M. HUGHES & MELVIN CALVIN

Authors
  1. URS R. JOSS
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  2. ANN M. HUGHES
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  3. MELVIN CALVIN
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JOSS, U., HUGHES, A. & CALVIN, M. Effect of Dimethylbenzyldesmethylrifampicin (DMB) on Chemically Induced Mammary Tumours in Rats. Nature New Biology 242, 88–90 (1973). https://doi.org/10.1038/newbio242088a0

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