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A case of an asymptomatic hypoechoic testicular mass in the setting of contralateral orchitis

Abstract

Background A 28-year-old heterosexual man presented to an emergency department with a 2-day history of left testicular pain and swelling that began after he started having unprotected sex with a new partner. He also had a 1-day history of fever and chills.

Investigations Physical examination, urinalysis, complete blood count, polymerase chain reaction testing for gonorrhea and chlamydia, serial scrotal ultrasonography with color Doppler imaging, and measurement of serum tumor marker levels.

Diagnosis Left orchitis with right testicular mass suspicious for malignancy.

Management The patient received antibiotic therapy (ceftriaxone and azithromycin), which resulted in resolution of his presenting symptoms. He was discharged from hospital with plans to undergo follow-up evaluation by the urology service. He opted to delay surgical intervention; repeat ultrasonography at 4 weeks revealed signs consistent with treated left-sided orchitis and revealed near-complete resolution of the right-sided lesion. The patient's right-sided mass probably represented subclinical bacterial orchitis, which responded to antibiotic therapy.

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Figure 1: Ultrasonography at presentation.
Figure 2: Repeat ultrasonography performed 4 weeks after the patient's original presentation.
Figure 3: Repeat ultrasonography performed approximately 4 months after the patient's initial presentation.

References

  1. Light D (online 30 October 2006) Testicle, Malignant Tumors. [http://www.emedicine.com/radio/topic680.htm] (accessed 12 December 2008)

  2. Horstman WG et al. (1991) Color Doppler US of the scrotum. Radiographics 11: 941–957

    Article  CAS  Google Scholar 

  3. Bilagi P et al. (2007) Clinical and ultrasound features of segmental testicular infarction: six-year experience from a single centre. Eur Radiol 17: 2810–2818

    Article  Google Scholar 

  4. Balzer BL and Ulbright TM (2006) Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol 30: 858–865

    Article  Google Scholar 

  5. Bayram MM and Kervancioglu R (1997) Scrotal gray-scale and color Doppler sonographic findings in genitourinary brucellosis. J Clin Ultrasound 25: 443–447

    Article  CAS  Google Scholar 

  6. Cook JL and Dewbury K (2000) The changes seen on high-resolution ultrasound in orchitis. Clin Radiol 55: 13–18

    Article  CAS  Google Scholar 

  7. Geisler WM and Kreiger JN (2007) Epididymitis and the acute scrotum syndrome. In Current Diagnosis and Treatment of Sexually Transmitted Diseases, 33–41 (Eds Klausner JD and Hook EW III) New York: McGraw–Hill

    Google Scholar 

  8. Cook RL et al. (2005) Systematic review: noninvasive testing for Chlamydia trachomatis and Neisseria gonorrhoeae. Ann Intern Med 142: 914–925

    Article  Google Scholar 

  9. Maloney GE Jr (online 15 January 2008). Brucellosis. [http://www.emedicine.com/emerg/TOPIC883.HTM] (accessed 12 December 2008)

  10. Centers for Disease Control and Prevention (online 12 April 2007) Updated Recommended Treatment Regimens for Gonococcal Infections and Associated Conditions—United States 2007. [http://www.cdc.gov/std/treatment/2006/GonUpdateApril2007.pdf] (accessed 12 December 2008)

  11. Centers for Disease Control and Prevention (online 20 December 2007) CDC Fact Sheet: Chlamydia [http://www.cdc.gov/std/chlamydia/chlamydia-fact-sheet.pdf] (accessed 12 December 2008)

  12. Zenilman J (2007) Urethral discharge. In Current Diagnosis and Treatment of Sexually Transmitted Diseases, 14–18 (Eds Klausner JD and Hook EW III) New York: McGraw–Hill

    Google Scholar 

  13. Powell TM and Tartar TH (2006) Management of nonpalpable incidental testicular masses. J Urol 176: 96–99

    Article  Google Scholar 

  14. Karam JA and Baker LA (2007) Focal orchitis presenting as bilateral testicular masses. J Pediatr Urol 3: 337–339

    Article  Google Scholar 

  15. Vaidyanathan S et al. (2008) Seminoma of testis masquerading as orchitis in an adult with paraplegia: proposed measures to avoid delay in diagnosing testicular tumours in spinal cord injury patients. ScientificWorldJournal 8: 149–156

    Article  Google Scholar 

  16. Plas E et al. (1997) Focal orchitis—a diagnostic dilemma. Br J Urol 79: 995–996

    Article  CAS  Google Scholar 

  17. Takashi I et al. (2002) Clinical investigation of male infertility in patients with a past history of mumps orchitis [Japanese]. Japanese Journal of Fertility and Sterility 47: 13–17

    Google Scholar 

  18. Colpi GM et al. (2006) Testicular-sparing microsurgery for suspected testicular masses. BJU Int 96: 67–69

    Article  Google Scholar 

Download references

Acknowledgements

Both authors would like to acknowledge the contributions made by John P Gay, MD, J Thomas Jones, MD, and Elizabeth Fitzpayne, the librarian of the Massachusetts Medical Society, who provided reference articles. Dr Morris would also like to acknowledge John G Gregory, MD, and Francis J McGovern, MD, for their support and encouragement in pursuit of his urological career; and the faculty and staff of the Massachusetts General Hospital for providing his urological training.

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Correspondence to Richard EA Morris.

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Morris, R., Guimaraes, A. A case of an asymptomatic hypoechoic testicular mass in the setting of contralateral orchitis. Nat Rev Urol 6, 108–112 (2009). https://doi.org/10.1038/ncpuro1291

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