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A division of labor: asymmetric roles for GPCR subunits in receptor dimers

Nature Chemical Biology volume 5, pages 608–609 (2009)Cite this article

The functional architecture of dimeric or oligomeric GPCR signaling remains incompletely understood. Using a clever combination of receptor–G protein fusions and various receptor mutations, new research provides a glimpse into how oligomers might be arranged with respect to the G proteins they interact with.

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Figure 1: Asymmetry of receptor subunits in dimeric GPCRs.

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  1. Peter Zylbergold and Terence E. Hébert are in the Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.,

    Peter Zylbergold & Terence E Hébert

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  1. Peter Zylbergold
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  2. Terence E Hébert
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Correspondence to Terence E Hébert.

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Zylbergold, P., Hébert, T. A division of labor: asymmetric roles for GPCR subunits in receptor dimers. Nat Chem Biol 5, 608–609 (2009). https://doi.org/10.1038/nchembio0909-608

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