Intrinsically disordered proteins (IDPs) are subject to ubiquitin-independent degradation, a default and passive process. We describe here a model wherein a group of 'nanny' proteins function to protect newly synthesized IDPs from degradation by default, thereby insuring their maturation into important regulatory molecules.
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Tsvetkov, P., Reuven, N. & Shaul, Y. The nanny model for IDPs. Nat Chem Biol 5, 778–781 (2009). https://doi.org/10.1038/nchembio.233
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DOI: https://doi.org/10.1038/nchembio.233
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