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Glutamate receptors

Mechanistic twists and turns

Nature Chemical Biology volume 10, pages 698–699 (2014)Cite this article

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Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory neurotransmission, which is crucial for memory and learning. New cryo-electron microscopy structures of these receptors trapped in distinct functional states provide remarkable insight into conformational changes triggered by agonist binding.

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Figure 1: Desensitization of ionotropic glutamate receptors.

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Authors and Affiliations

  1. Kasper B. Hansen is in the Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, USA.,

    Kasper B Hansen

  2. Stephen F. Traynelis is in the Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA.,

    Stephen F Traynelis

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  1. Kasper B Hansen
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  2. Stephen F Traynelis
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Correspondence to Stephen F Traynelis.

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The authors declare no competing financial interests.

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Hansen, K., Traynelis, S. Mechanistic twists and turns. Nat Chem Biol 10, 698–699 (2014). https://doi.org/10.1038/nchembio.1614

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