Carbonates are known to exist in natural products, but their biosynthesis has not been linked to any enzymes. An unusual fungal Baeyer-Villiger monooxygenase CcsB is now revealed to catalyze an in-line carbonate formation via a two-step mechanism of oxygen atom insertions.
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Sun, Y. A carbonate architect emerges. Nat Chem Biol 10, 486–487 (2014). https://doi.org/10.1038/nchembio.1531
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DOI: https://doi.org/10.1038/nchembio.1531
