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Membrane proteins

Through thick and thin

The nicotinic acetylcholine receptor (nAChR) is regulated by changes in the host lipid bilayer composition and has been studied extensively to elucidate the relative importance of specific lipid-protein interactions versus more general nonspecific bilayer-protein interactions in the regulation of membrane protein function. Experiments reported in this issue provide strong support for the importance of lipid bilayer physical properties and lipid bilayer–membrane protein hydrophobic mismatch in the regulation of nAChR function.

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Figure 1: Lipid bilayer regulation of nAChR function.

References

  1. Criado, M., Eibl,H. & Barrantes, F.J. J. Biol. Chem. 259, 9188–9198 (1984).

    CAS  PubMed  Google Scholar 

  2. Fong, T.M. & McNamee, M.G. Biochemistry 25, 830–840 (1986).

    Article  CAS  Google Scholar 

  3. daCosta, C.J. et al. J. Biol. Chem. 284, 33841–33849 (2009).

    Article  CAS  Google Scholar 

  4. Sunshine, C. & McNamee, M.G. Biochim. Biophys. Acta 1108, 240–246 (1992).

    Article  CAS  Google Scholar 

  5. Katz, B. & Thesleff, S. J. Physiol. (Lond.) 138, 63–80 (1957).

    Article  CAS  Google Scholar 

  6. Herz, J.M., Johnson, D.A. & Taylor, P. J. Biol. Chem. 262, 7238–7247 (1987).

    CAS  PubMed  Google Scholar 

  7. daCosta, C.J. & Baenziger, J.E. J. Biol. Chem. 284, 17819–17825 (2009).

    Article  CAS  Google Scholar 

  8. daCosta, C.J. et al. Nat. Chem. Biol. 9, 701–707 (2013).

    Article  CAS  Google Scholar 

  9. Levine, Y.K. & Wilkins, M.H. Nat. New Biol. 230, 69–72 (1971).

    Article  CAS  Google Scholar 

  10. Evans, E. & Rawicz, W. Phys. Rev. Lett. 64, 2094–2097 (1990).

    Article  CAS  Google Scholar 

  11. Marsh, D. Biochim. Biophys. Acta 1778, 1545–1575 (2008).

    Article  CAS  Google Scholar 

  12. Fattal, D.R. & Ben-Shaul, A. Biophys. J. 65, 1795–1809 (1993).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Olaf S Andersen.

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Andersen, O. Through thick and thin. Nat Chem Biol 9, 667–668 (2013). https://doi.org/10.1038/nchembio.1368

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