New, bioactive marine sponge compounds that function as inhibitors of the poly (ADP-ribose) polymerase family of proteins have now been identified to promote the correction of cystic fibrosis. Poly (ADP-ribose) polymerase inhibitors may be managers of proteostasis biology, consistent with their role (or roles) in remediation of inflammatory states.
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Gupta, V., Balch, W. Salty sea regulators of cystic fibrosis. Nat Chem Biol 9, 12–14 (2013). https://doi.org/10.1038/nchembio.1144
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DOI: https://doi.org/10.1038/nchembio.1144
