Bacterial persisters consist of a phenotypic subpopulation that survives antibiotic treatment, prolonging infection. The GhoT toxin from the newly discovered ghoS-ghoT toxin-antitoxin system contributes to persistence, most likely by interfering with bacterial inner membrane integrity.
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Van Melderen, L. GhoSTly bacterial persisters. Nat Chem Biol 8, 812–813 (2012). https://doi.org/10.1038/nchembio.1066
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DOI: https://doi.org/10.1038/nchembio.1066