DNA self-assembly has previously been used to create channel-like structures that can penetrate through lipid bilayer membranes. However, such assemblies have not been shown to cause cell death before. Now a DNA nanopore has been shown to exert a cytotoxic effect when administered to cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Fjell, C. D., Hiss, J. A., Hancock, R. E. W. & Schneider, G. Nature Rev. Drug Discov. 11, 37–51 (2011).
Gaspar, D., Veiga, A. S. & Castanho, M. A. R. B. Front. Microbiol. 4, 1–16 (2013).
Burns, J. R., Al-Juffali, N., Janes, S. M. & Howorka, S. Angew. Chem. Int. Ed. 53, 12466–12470 (2014).
Rothemund, P. W. K. Nature 440, 297–302 (2006).
Douglas, S. M. et al. Nature 459, 414–418 (2009).
Langecker, M. et al. Science 338, 932–936 (2012).
Burns, J. R., Stulz, E. & Howorka, S. Nano Lett. 13, 2351–2356 (2013).
Burns, J. R. et al. Angew. Chem. Int. Ed. 52, 12069–12072 (2013).
Yin, P. et al. Science 321, 824–826 (2008).
Douglas, S. M., Bachelet, I. & Church, G. M. Science 335, 831–834 (2012).
Hahn, J., Wickham, S. F. J., Shih, W. M. & Perrault, S. D. ACS Nano 8, 8765–8775 (2014).
Perrault, S. D. & Shih, W. M. ACS Nano 8, 5132–5140 (2014).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Krishnan, S., Simmel, F. Deadly DNA. Nature Chem 7, 17–18 (2015). https://doi.org/10.1038/nchem.2148
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.2148
