Two studies show that the E3 ubiquitin ligase RNF138 is recruited to DNA double-strand break sites, where it ubiquitylates key repair factors to promote DNA-end resection and homologous recombination. These findings add insights into the multilayered regulatory mechanisms underlying DNA double-strand break repair pathway choice in mammalian cells.
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Bekker-Jensen, S., Mailand, N. RNF138 joins the HR team. Nat Cell Biol 17, 1375–1377 (2015). https://doi.org/10.1038/ncb3262
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DOI: https://doi.org/10.1038/ncb3262
