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FOXO flips the longevity SWItch

Nature Cell Biology volume 15, pages 444–446 (2013)Cite this article

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FOXO transcription factors promote longevity from worms to mammals, but the mechanisms by which FOXO extends lifespan have remained elusive. In the nematode Caenorhabditis elegans, FOXO is now shown to recruit the nucleosome remodelling complex SWI/SNF to its target genes, which is essential for FOXO to elicit stress resistance and longevity.

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Figure 1: The role of SWI/SNF in FOXO-dependent transcription of longevity and stress-resistance genes.

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Authors and Affiliations

  1. Ashley E. Webb and Anne Brunet are in the Department of Genetics, Stanford University, Stanford, California 94305, USA,

    Ashley E. Webb & Anne Brunet

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  1. Ashley E. Webb
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  2. Anne Brunet
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Correspondence to Anne Brunet.

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The authors declare no competing financial interests.

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Webb, A., Brunet, A. FOXO flips the longevity SWItch. Nat Cell Biol 15, 444–446 (2013). https://doi.org/10.1038/ncb2749

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