Cytoplasmic dynein drives vesicular transport from the periphery to the cell body of neurons. Missense mutations in the dynein tail domain cause neurodegenerative disease in mouse models. New data on the effect of one such dynein mutation provide insight into the intramolecular communication and flexible stepping of this essential cellular motor.
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Hendricks, A., Lazarus, J. & Holzbaur, E. Dynein at odd angles?. Nat Cell Biol 12, 1126–1128 (2010). https://doi.org/10.1038/ncb1210-1126
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DOI: https://doi.org/10.1038/ncb1210-1126
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