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Closing in on vertebrate planar polarity

Nature Cell Biology volume 6, pages 687–689 (2004)Cite this article

Convergent extension — a key tissue movement during vertebrate embryogenesis — requires precise control of cell polarity, which is regulated through a planar cell polarity pathway that is conserved across invertebrates. The identification of two new factors regulating convergent extension suggests that vertebrates may have introduced intriguing modifications of the planar cell polarity pathway to regulate morphogenesis.

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Figure 1: Convergent extension and planar polarity.
Figure 2: The vertebrate planar cell polarity cascade — simplified.

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  1. the Section of Molecular Cell and Developmental Biology & Institute for Cellular and Molecular Biology, 1 University Station C0930, University of Texas, Austin, 78712, Tx, USA

    John B. Wallingford

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  1. John B. Wallingford
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Wallingford, J. Closing in on vertebrate planar polarity. Nat Cell Biol 6, 687–689 (2004). https://doi.org/10.1038/ncb0804-687

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