Store-operated Ca2+ channels (SOCs) are activated in response to Ca2+ release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca2+ content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.
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STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function
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Shin, D., Muallem, S. Skeletal muscle dressed in SOCs. Nat Cell Biol 10, 639–641 (2008). https://doi.org/10.1038/ncb0608-639
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DOI: https://doi.org/10.1038/ncb0608-639
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