It has long been known that the mammalian small GTPase Rab5 is involved in clathrin-mediated endocytosis. However, most Rab5-interacting proteins are localized to endosomes rather than to the plasma membrane. A newly discovered nucleotide-exchange factor for Rab5 in Caenorhabditis elegans now provides the missing link for activating Rab5 at the plasma membrane.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Colicelli, J. Sci. STKE 2004, RE13 (2004).
Zerial, M. & McBride, H. Nature Rev. Mol. Cell Biol. 2, 107–117 (2001).
Sato, M. et al. Nature Cell Biol. 7, 559–569 (2005).
Gorvel, J.P., Chavrier, P., Zerial, M. & Gruenberg, J. Cell 64, 915–925 (1991).
Stenmark, H. et al. EMBO J. 13, 1287–1296 (1994).
de Renzis, S., Sonnichsen, B. & Zerial, M. Nature Cell Biol. 4, 124–133 (2002).
Tall, G.G., Barbieri, M.A., Stahl, P.D. & Horazdovsky, B.F. Dev. Cell 1, 73–82 (2001).
Lanzetti, L., Palamidessi, A., Areces, L., Scita, G. & Di Fiore, P.P. Nature 429, 309–314 (2004).
Miaczynska, M. et al. Cell 116, 445–456 (2004).
Bucci, C. et al. Cell 70, 715–728 (1992).
Horiuchi, H. et al. Cell 90, 1149–1159 (1997).
Otomo, A. et al. Hum. Mol. Genet. 12, 1671–1687 (2003).
McLauchlan, H. et al. Curr. Biol. 8, 34–45 (1998).
Horiuchi, H., Giner, A., Hoflack, B. & Zerial, M. J. Biol. Chem. 270, 11257–11262 (1995).
Grant, B. & Hirsh, D. Mol. Biol. Cell 10, 4311–4326 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
van der Bliek, A. A sixth sense for Rab5. Nat Cell Biol 7, 548–550 (2005). https://doi.org/10.1038/ncb0605-548
Issue Date:
DOI: https://doi.org/10.1038/ncb0605-548