It has long been known that the mammalian small GTPase Rab5 is involved in clathrin-mediated endocytosis. However, most Rab5-interacting proteins are localized to endosomes rather than to the plasma membrane. A newly discovered nucleotide-exchange factor for Rab5 in Caenorhabditis elegans now provides the missing link for activating Rab5 at the plasma membrane.
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van der Bliek, A. A sixth sense for Rab5. Nat Cell Biol 7, 548–550 (2005). https://doi.org/10.1038/ncb0605-548
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DOI: https://doi.org/10.1038/ncb0605-548
