The activation and targeted localization of ubiquitin E2 conjugating enzymes could provide a point for regulating ubiquitin-dependent cell functions. Supporting this view, the ubiquitin charging and activation of a class of E2 enzymes has been directly linked to their nuclear import.
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Zhang, XD., Matunis, M. Ub in charge: Regulating E2 enzyme nuclear import. Nat Cell Biol 7, 12–14 (2005). https://doi.org/10.1038/ncb0105-12
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DOI: https://doi.org/10.1038/ncb0105-12
