Abstract
Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.
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Gilbert, S., Plebanski, M., Harris, S. et al. A protein particle vaccine containing multiple malaria epitopes. Nat Biotechnol 15, 1280–1284 (1997). https://doi.org/10.1038/nbt1197-1280
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DOI: https://doi.org/10.1038/nbt1197-1280
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