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Refining the telomere-telomerase hypothesis of aging and cancer

Nature Biotechnology volume 14, pages 836–839 (1996)Cite this article

Abstract

While there has been substantial experimental evidence in support of the telomere-telomerase hypothesis of aging and cancer, it has been suggested that the theory has been oversimplified to the exclusion of alternative mechanisms in the progression of cancer. This review strives to present an overview of some of the areas that have not been well explained and to indicate where multiple interpretations of the data are possible.

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Author notes

  1. Jerry W. Shay: email: shay@utsw.swmed.edu

Authors and Affiliations

  1. Department of Cell Biology and Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75235-9039

    Shawn E. Holt

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Holt, S., Shay, J. & Wright, W. Refining the telomere-telomerase hypothesis of aging and cancer. Nat Biotechnol 14, 836–839 (1996). https://doi.org/10.1038/nbt0796-836

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