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Virtual Spectroscopy for Fun and Profit

Abstract

A physicomathematical approach to decoding the relationship between amino acid sequence and protein function may provide a novel way of designing biologically active peptides

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References

  1. Kanochisa, M. 1988. A multivariant analysis method for discriminating protein secondary structural segments. Protein Engineering 2: 87–92.

    Article  Google Scholar 

  2. Nakai, K., Kidera, A., and Kanechisa, M. 1988. Cluster analysis of amino acid indices for prediction of protein structure and function. Protein Engineering 2: 93–100.

    Article  CAS  Google Scholar 

  3. Cosic, I. 1994. Macromolecular bioactivity: Is it resonant interaction between macromolecules?-Theory and applications. IEEE Transactions on Biomedical Engineering 41 12: 1101–1114.

    Article  Google Scholar 

  4. Cosic, I.M., and Vojisavljevic, V. 1989. Prediction of “hot spots” in interleukin-2. based on informational spectrum, characteristics of growth regulating factors. Biochimie 3: 333–342.

    Article  Google Scholar 

  5. Cosic I. and Hearn, M.T. 1991. “Hot spot” amino acid distribution in Ha-ras oncogene product p21: relationship to guanine binding site. J. Molecular Recognition 4: 57–62.

    Article  CAS  Google Scholar 

  6. Cosic, I. and Nesic, D. 1988. Prediction of “hot spots” in SV40 enhancer and relation with experimental data. Eur. J. Biochem. 170: 247–252.

    Article  Google Scholar 

  7. Cosic, I., Drummond, A.E., Underwood, J.R. and Hearn, M.T.W. 1994. A new approach to growth factor analogue design: modelling of FGF analogues. Molecular and Cellular Biochem. 130: 1–9.

    Article  CAS  Google Scholar 

  8. Krsmanovic, V., Cosic, I., Biquard, J.M., and Hearn, M.T.V. 1993. Artificial peptides and induced antibodies. Patent number WO93/17108.

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Cosic, I. Virtual Spectroscopy for Fun and Profit. Nat Biotechnol 13, 236–238 (1995). https://doi.org/10.1038/nbt0395-236

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