Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

A piece of the p53 puzzle

An iron-dependent form of cell death called ferroptosis has been implicated as a component of the tumour-suppressor activity of p53, providing fresh insight into how this protein prevents cancer development. See Article p.57

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The functions of p53 in tumour suppression.

Notes

  1. See all news & views

References

  1. Freed-Pastor, W. A. & Prives, C. Genes Dev. 26, 1268–1286 (2012).

    Article  CAS  Google Scholar 

  2. Jiang, L. et al. Nature 520, 57–62 (2015).

    Article  ADS  CAS  Google Scholar 

  3. Lane, D. P. Nature 358, 15–16 (1992).

    Article  ADS  CAS  Google Scholar 

  4. Vousden, K. H. & Prives, C. Cell 137, 413–431 (2009).

    Article  CAS  Google Scholar 

  5. Brady, C. A. et al. Cell 145, 571–583 (2011).

    Article  CAS  Google Scholar 

  6. Li, T. et al. Cell 149, 1269–1283 (2012).

    Article  CAS  Google Scholar 

  7. Valente, L. J. et al. Cell Rep. 3, 1339–1345 (2013).

    Article  CAS  Google Scholar 

  8. Conrad, M. & Sato, H. Amino Acids 42, 231–246 (2012).

    Article  CAS  Google Scholar 

  9. Dixon, S. J. et al. Cell 149, 1060–1072 (2012).

    Article  CAS  Google Scholar 

  10. Bieging, K. T., Mello, S. S. & Attardi, L. D. Nature Rev. Cancer 14, 359–370 (2014).

    Article  CAS  Google Scholar 

  11. Yang, W. S. et al. Cell 156, 317–331 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Laura D. Attardi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bieging, K., Attardi, L. A piece of the p53 puzzle. Nature 520, 37–38 (2015). https://doi.org/10.1038/nature14374

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature14374

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer