The MTH1 protein prevents oxidized nucleotides from being misincorporated into DNA. Two studies find that selective inhibition of MTH1 by small molecules suppresses tumour growth. See Articles p.215 & p.222
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Dominissini, D., He, C. Damage prevention targeted. Nature 508, 191–192 (2014). https://doi.org/10.1038/nature13221
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DOI: https://doi.org/10.1038/nature13221
