Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Physiology

Inflammation links ageing to the brain

Inflammation-activated signalling pathways in the brain's hypothalamus control the production of ageing-related hormones. This finding provides a link between inflammation, stress responses and systemic ageing. See Article p.211

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Hypothalamic inflammation and control of systemic ageing.

Notes

  1. *This article and the paper under discussion were published online on 1 May 2013.

References

  1. Zhang, G. L. J. et al. Nature 497, 211–216 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Alcedo, J. & Kenyon, C. Neuron 41, 45–55 (2004).

    Article  CAS  Google Scholar 

  3. Bishop, N. A. & Guarente, L. Nature 447, 545–549 (2007).

    Article  ADS  CAS  Google Scholar 

  4. Fridell, Y. W., Sanchez-Blanco, A., Silvia, B. A. & Helfand, S. L. Cell Metab. 1, 145–152 (2005).

    Article  CAS  Google Scholar 

  5. Adler, A. S. et al. Genes Dev. 21, 3244–3257 (2007).

    Article  CAS  Google Scholar 

  6. Franceschi, C. et al. Mech. Ageing Dev. 128, 92–105 (2007).

    Article  CAS  Google Scholar 

  7. Osborn, O. & Olefsky, J. M. Nature Med. 18, 363–374 (2012).

    Article  CAS  Google Scholar 

  8. Bishop, N. A., Lu, T. & Yankner, B. A. Nature 464, 529–535 (2010).

    Article  ADS  CAS  Google Scholar 

  9. Green, D. R., Galluzzi, L. & Kroemer, G. Science 333, 1109–1112 (2011).

    Article  ADS  CAS  Google Scholar 

  10. Kepp, O., Galluzzi, L. & Kroemer, G. Nature Immunol. 12, 199–200 (2011).

    Article  CAS  Google Scholar 

  11. Herde, M. K., Geist, K., Campbell, R. E. & Herbison, A. E. Endocrinology 152, 3832–3841 (2011).

    Article  CAS  Google Scholar 

  12. Stevenson, T. J., Hahn, T. P., MacDougall-Shackleton, S. A. & Ball, G. F. Front. Neuroendocrinol. 33, 287–300 (2012).

    Article  CAS  Google Scholar 

  13. Waterland, R. A. & Michels, K. B. Annu. Rev. Nutr. 27, 363–388 (2007).

    Article  CAS  Google Scholar 

  14. McGowan, P. O. et al. Nature Neurosci. 12, 342–348 (2009).

    Article  CAS  Google Scholar 

  15. Munhoz, C. D., Sorrells, S. F., Caso, J. R., Scavone, C. & Sapolsky, R. M. J. Neurosci. 30, 13690–13698 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Dana Gabuzda or Bruce A. Yankner.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gabuzda, D., Yankner, B. Inflammation links ageing to the brain. Nature 497, 197–198 (2013). https://doi.org/10.1038/nature12100

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12100

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing