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Cytogenetics and Molecular Genetics

Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China

Leukemia volume 23, pages 1801–1806 (2009)Cite this article

Abstract

Geographic heterogeneity of cytogenetic patterns in hematological malignancies has been reported earlier, but few systematic studies of cytogenetic abnormalities in acute myeloid leukemia (AML) patients are available. We examined the karyotypic patterns in 1432 de novo AML patients from a single center in China and compared our data with reports from other regions of the world. Chromosomal abnormalities were detected in 746 (58%) cases. The most frequent cytogenetic abnormality was t(15;17), detected in 14% of successful cases, followed by t(8;21) in 8%, and t(9;22), +21 and +8 each in 2%. The mean age of patients with a translocation karyotype was significantly younger than that of patients with normal, deletion or trisomy karyotypes. A higher incidence of AML M3 and a lower frequency of M4 were observed in the Asian population and the frequencies of certain cytogenetic aberrations were different from those in the earlier reports. Population-based age-specific incidences of AML were calculated and compared with those in western reports.

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Acknowledgements

We thank Dr Janet D Rowley from the University of Chicago Medical Center, IL, USA, for critical review of the manuscript. We also thank Dr Gang Ye for grammatical and cosmetic polishing in English writing. This work was supported in part by the Chinese National High Tech Program (863) (2006AA02Z413) (Principal Investigator: Saijuan Chen; E-mail: sjchen@stn.sh.cn), the National Natural Science Foundation of China, Zhejiang Province Commission for Science and Technology research Foundation (Principal Investigator: Jie Jin; E-mail: jiej@hzcnc.com). Yizhi Cheng designed and performed research, analyzed data and wrote the manuscript; Yungui Wang was responsible for the RT-PCR section; Huanping Wang analyzed data and performed research; Zhimei Chen performed research; Jiyu Lou performed research; Huan Xu performed research; Huafeng Wang collected and reviewed cytogenetic data; Wenbin Qian collected and reviewed the medical records; Haitao Meng collected and reviewed the medical records; Maofang Lin reviewed the medical records; Jie Jin designed research and reviewed the manuscript.

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  1. Y Cheng and Y Wang: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China

    Y Cheng, H Wang, W Qian, H Meng, M Lin & J Jin

  2. Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, PR China

    Y Cheng, Y Wang, H Wang, Z Chen, J Lou, H Xu, H Wang, W Qian, H Meng, M Lin & J Jin

  3. Key Laboratory of Hematopoietic Malignancies, Zhejiang Province, Hangzhou, Zhejiang, PR China

    Y Cheng, Y Wang, H Wang, Z Chen, J Lou, H Xu, W Qian, H Meng & J Jin

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Correspondence to J Jin.

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Cheng, Y., Wang, Y., Wang, H. et al. Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China. Leukemia 23, 1801–1806 (2009). https://doi.org/10.1038/leu.2009.107

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