ArticleDifferentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology
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Supplementary Information accompanies the paper on the Laboratory Investigation website
Autosomal dominant osteopetrosis type II (ADO II) is caused by mutations in the CLCN7 voltage-gated chloride channel and is characterized by high bone mass and insufficient osteoclast activity. The authors identified additional changes in gene expression in osteoclasts from patients with ADO II using transcriptomics, qPCR, and transfection studies. They found elevated expression of integrin beta-5 and reduced expression of trp-tRNA synthetase, perforin 1 (a pore-forming protein) and SERPINE2 (a serine protease inhibitor).
Supplementary information The online version of this article (doi:10.1038/labinvest.2013.140) contains supplementary material, which is available to authorized users.