Research ArticleGastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature
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Keywords
animal model
DCLK1
forestomach
gastric tumor development
Smad3
SPEM
tuft cell
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Smad3-deficient mice develop gastric tumors in the fundus, which arise from the junction between the forestomach and the glandular epithelium and progress to prominent invasive tumors over time. Smad3 null mice therefore represent a novel model of fundic gastric tumorigenesis.
© 2012 United States & Canadian Academy of Pathology.