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Experimental models of arteriogenesis: differences and implications

Lab Animal volume 35, pages 36–44 (2006)Cite this article

Abstract

Cardiovascular and cerebrovascular disease represent the two most common causes of mortality and morbidity in western countries, and the treatment for these is generally by the mechanical restoration of blood flow in the affected tissues. Stimulation of collateral artery growth (arteriogenesis) provides a potential alternative option for the treatment of patients suffering from occlusive artery disease. Therefore, researchers have established several angiogenesis and arteriogenesis animal models to investigate basic mechanisms and pharmacological modulation of collateral artery growth. The authors highlight the most important aspects of vascular growth, discuss different methods and techniques for examining the process, and review the advantages and disadvantages associated with the animal models available for studying this phenomenon.

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Figure 1: Angiogenesis and arteriogenesis.
Figure 2: Post-mortem angiograms of rabbit hindlimbs.
Figure 3: Laser Doppler flow imaging in a murine hindlimb model.
Figure 4: Selecting the right model for arteriogenic studies.

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Author information

Authors and Affiliations

  1. Department of Experimental Cardiology, UMC, University of Utrecht, The Netherlands

    Imo E. Hoefer MD, PhD

  2. Department of Cardiology, AMC, University of Amsterdam, The Netherlands

    Niels van Royen MD, PhD

  3. BioVisioN AG, Medical Research, Hannover, 30625, Germany

    Marco M. Jost PhD

Authors
  1. Imo E. Hoefer MD, PhD
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  2. Niels van Royen MD, PhD
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  3. Marco M. Jost PhD
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Correspondence to Imo E. Hoefer MD, PhD.

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Competing interests

Hoefer and van Royen are shareholders of Perfusion Technologies GmbH, Freiburg, Germany.

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Hoefer, I., van Royen, N. & Jost, M. Experimental models of arteriogenesis: differences and implications. Lab Anim 35, 36–44 (2006). https://doi.org/10.1038/laban0206-36

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