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Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case–control study of gc globulin and bronchopulmonary dysplasia

Journal of Perinatology volume 35, pages 763–767 (2015)Cite this article

Subjects

Abstract

Objective:

The pathophysiologies of bronchopulmonary dysplasia (BPD) are inflammation, infection, tissue damage, angiogenesis defects and genetic susceptibility. Because of the role of the vitamin D binding protein (Gc globulin) on these factors, we investigated the relationship between Gc globulin polymorphisms and BPD.

Study design:

This case-control study was performed with 160 neonates (⩽32 gestational ages, ⩽1500 g). PCR DNA sequence analyses were used for GC gene rs4588 and rs7041 single-nucleotide polymorphisms.

Result:

In the univariate analyses, it was observed that Gc2 was the only variant that was protective against BPD (Odd ratio (OR)=0.47, 95% coinfidence interval (CI)=0.24 to 0.89, P=0.020). In the multivariate analyses, Gc2 decreased the risk of disease (OR=0.15, 95% CI=0.029 to 0.79, P=0.026) independent of gestational age, birth weight, 5-min Appearance, Pulse, Grimace, Activity, and Respiration scores, respiratory distress syndrome and sepsis.

Conclusion:

The Gc2 variant was, after adjusting for confounders, associated with a decrease in the frequency of BPD. Our study adds Gc globulin to the list of candidate genes that potentially contribute to the etiology of the disease.

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Authors and Affiliations

  1. Zeynep Kamil Maternity and Children’s Training and Research Hospital, Neonatology Unit, Istanbul, Turkey

    O Serce Pehlevan, G Karatekin, D Benzer, T Gursoy & F Ovali

  2. Burc Genetic Diagnosis Center, Istanbul, Turkey

    V Koksal

  3. Zeynep Kamil Maternity and Children’s Training and Research Hospital, Pediatric Cardiology Unit, Istanbul, Turkey

    T Yavuz

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  1. O Serce Pehlevan
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  2. G Karatekin
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Correspondence to O Serce Pehlevan.

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Serce Pehlevan, O., Karatekin, G., Koksal, V. et al. Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case–control study of gc globulin and bronchopulmonary dysplasia. J Perinatol 35, 763–767 (2015). https://doi.org/10.1038/jp.2015.58

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