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Inflammatory mediator patterns in tracheal aspirate and their association with bronchopulmonary dysplasia in very low birth weight neonates

Journal of Perinatology volume 33, pages 383–387 (2013)Cite this article

Subjects

Abstract

Objective:

Alterations in inflammatory mediators are an important finding in neonates who develop bronchopulmonary dysplasia (BPD); however, there is a lack of research examining the relationship between multiple inflammatory mediators in premature neonates and the development of BPD. This study investigated whether the distribution of 12 inflammatory mediators detected in the tracheal aspirate (TA) of neonates within 24 h of birth could differentiate between neonates who did and who did not develop BPD.

Study design:

TA samples were collected from 27 very low birth weight neonates (BPD+=11), and the concentrations of 12 biomarkers associated with BPD were determined. Linear discriminant analysis (LDA) was used to classify neonates into two outcome groups.

Result:

LDA based on the 12 measured biomarkers displayed a significant level of discriminant function (P=0.007).

Conclusion:

Using linear discriminant analysis, predictive models of BPD can be generated. Our results suggest that multiple inflammatory mediators collected within 24 h of birth may be used to classify neonates into who will and who will not develop BPD.

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Acknowledgements

This study was supported in part by PHS Grant (TL1 RR025010) from the Clinical and Translational Science Award Program, National Institutes of Health, National Center for Research Resources (KRS) and the Childrens Healthcare of Atlanta Center for Developmental Lung Biology (TWG and LAB).

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Authors and Affiliations

  1. Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA

    K R Schneibel, A M Fitzpatrick, X-D Ping, L A S Brown & T W Gauthier

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  1. K R Schneibel
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  2. A M Fitzpatrick
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  3. X-D Ping
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  4. L A S Brown
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  5. T W Gauthier
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Correspondence to T W Gauthier.

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The authors declare no conflict of interest.

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Schneibel, K., Fitzpatrick, A., Ping, XD. et al. Inflammatory mediator patterns in tracheal aspirate and their association with bronchopulmonary dysplasia in very low birth weight neonates. J Perinatol 33, 383–387 (2013). https://doi.org/10.1038/jp.2012.125

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  • DOI: https://doi.org/10.1038/jp.2012.125

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