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Congenital collision tumors, neonatal renal mesoblastic nephroma and pararenal paraganglioma

Journal of Perinatology volume 29, pages 714–716 (2009)Cite this article

The surgical specimen from the nephroadrenalectomy showed a collision tumor containing a large classic mesoblastic nephroma and an adjacent renal hilar paraganglioma.

Mesoblastic nephroma (MN) is now known to be a rare fibroblastic low-grade sarcomatous tumor of the kidney.1 The overwhelming majority of cases (more than 90%) are diagnosed before 1 year of age, and none have been seen beyond 3 year of age. Histologically MN can be divided into a classic type consisting of monomorphous spindle cells with rare mitoses and with a generally good prognosis, and a cellular or atypical variety with dense sheets of cells with high nuclear–cytoplasmic ratio, high mitotic activity and a more aggressive course.2 The histological nature of the tumor does not always predict the clinical behavior and propensity to metastasize.1 The classic variety is twice more common than the cellular atypical variety. Interestingly, there may be entrapped renal tubules in MN peripherally, which may have a pathologically primitive appearance but do not indicate neoplastic renal tubular elements.1 These tubules may occasionally function.3 Recently, the cellular atypical variety of MN, but not the classic MN, has been shown to have the same chromosomal translocation and chromosomal fusion found in infantile fibrosarcoma.1 This has helped to confirm the fibroblastic origin of MN.

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  1. Department of Radiology, Mallinckrodt Institute of Radiology, St Louis Children's Hospital, Washington University School of Medicine, St Louis, MO, USA

    T E Herman & M J Siegel

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  1. T E Herman
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  2. M J Siegel
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Correspondence to T E Herman.

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Herman, T., Siegel, M. Congenital collision tumors, neonatal renal mesoblastic nephroma and pararenal paraganglioma. J Perinatol 29, 714–716 (2009). https://doi.org/10.1038/jp.2009.103

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