Abstract
Cunninghamella elegans has been employed for the biotransformation of cinobufagin to afford 5 metabolites. The structures of the transformation products have been characterized as 12α-hydroxybufagin, 11α-hydroxybufagin, 12β-hydroxy-desacetylcinobufagin, 3-oxo-12α-hydroxybufagin and 12β-hydroxybufagin. Products 12α-hydroxybufagin and 11α-hydroxybufagin are new compounds. In vitro both the biotransformation products and cinobufagin all showed cytotoxic activities against HeLa cells.
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Qiao, L., Zhou, Yz., Qi, Xl. et al. Biotransformation of Cinobufagin by Cunninghamella elegans. J Antibiot 60, 261–264 (2007). https://doi.org/10.1038/ja.2007.32
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DOI: https://doi.org/10.1038/ja.2007.32