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Salivary composition in obese vs normal-weight subjects: towards a role in postprandial lipid metabolism?

International Journal of Obesity volume 39, pages 1425–1428 (2015)Cite this article

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Abstract

In the pathophysiological context of obesity, oral exposure to dietary fat can modulate lipid digestion and absorption, but underlying in-mouth mechanisms have not been clearly identified. Therefore, we tested the hypothesis that salivary components related to dietary fat sensitivity would differ according to body mass index (BMI) and postprandial lipid metabolism in young men. Saliva was collected from nine normal-weight (BMI=22.3±0.5 kg m−2) and nine non-morbid obese (BMI=31.7±0.3 kg m−2) men before an 8-h postprandial metabolic exploration test involving the consumption of a 40-g fat meal, in which obese subjects revealed a delayed postprandial lipid metabolism. Nine salivary characteristics (flow, protein content, lipolysis, amylase, proteolysis, total antioxidant status, lysozyme, lipocalin 1 and carbonic anhydrase-VI) were investigated. We show that, under fasting conditions, salivary lipolysis was lower in obese vs normal-weight subjects, whereas proteolysis and carbonic anhydrase VI were higher. We reveal through multivariate and Mann–Whitney analysis that differences in fasting salivary lipolysis and proteolysis between both groups are related to differences in postprandial lipid metabolism including exogenous fatty-acid absorption and β-oxidation. These results suggest a potential role of salivary composition on postprandial lipid metabolism and bring novel causal hypotheses on the links between salivary composition, sensitivity to dietary fat oral income and postprandial lipid metabolism according to BMI.

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References

  1. Vors C, Pineau G, Gabert L, Drai J, Louche-Pelissier C, Defoort C et al. Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial. Am J Clin Nutr 2013; 97: 23–36.

    Article  CAS  Google Scholar 

  2. Mattes RD . Is there a fatty acid taste? Annu Rev Nutr 2009; 29: 305–327.

    Article  CAS  Google Scholar 

  3. Spielmann N, Wong DT . Saliva: diagnostics and therapeutic perspectives. Oral Dis 2011; 17: 345–354.

    Article  CAS  Google Scholar 

  4. Mandel AL, Breslin PAS . High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adults. J Nutr 2012; 142: 853–858.

    Article  CAS  Google Scholar 

  5. Feron G, Poette J . In-mouth mechanism leading to the perception of fat in humans: from detection to preferences. The particular role of saliva. OCL 2013; 20: 102–107.

    Article  Google Scholar 

  6. Sarkar A, Singh H Oral behaviour of food emulsions In: Chen J, Engelen L(eds) Food Oral Processing. Wiley-Blackwell: UK: UK, 2012. pp 111–137.

    Book  Google Scholar 

  7. Mounayar R, Septier C, Chabanet C, Feron G, Neyraud E . Oral fat sensitivity in humans: links to saliva composition before and after stimulation by oleic acid. Chemosens Percept 2013; 6: 118–126.

    Article  CAS  Google Scholar 

  8. Mounayar R, Morzel M, Brignot H, Tremblay-Franco M, Canlet C, Lucchi G et al. Salivary markers of taste sensitivity to oleic acid: a combined proteomics and metabolomics approach. Metabolomics 2013; 1–9.

  9. Neyraud E, Palicki O, Schwartz C, Nicklaus S, Feron G . Variability of human saliva composition: possible relationships with fat perception and liking. Arch Oral Biol 2012; 57: 556–566.

    Article  CAS  Google Scholar 

  10. Benjamini Y, Hochberg Y . Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995; 57: 289–300.

    Google Scholar 

  11. Piombino P, Genovese A, Esposito S, Moio L, Cutolo PP, Chambery A et al. Saliva from obese individuals suppresses the release of aroma compounds from wine. PLoS One 2014; 9: e85611.

    Article  Google Scholar 

  12. Chong IG, Jun CH . Performance of some variable selection methods when multicollinearity is present. Chemom Intell Lab Syst 2005; 78: 103–112.

    Article  CAS  Google Scholar 

  13. Schiffman SS, Dackis C . Taste of nutrients—amino-acids, vitamins, and fatty-acids. Percept Psychophys 1975; 17: 140–146.

    Article  Google Scholar 

  14. Dsamou M, Palicki O, Septier C, Chabanet C, Lucchi G, Ducoroy P et al. Salivary protein profiles and sensitivity to the bitter taste of caffeine. Chem Senses 2012; 37: 87–95.

    Article  CAS  Google Scholar 

  15. Bartoshuk LM, Duffy VB, Hayes JE, Moskowitz HR, Snyder DJ . Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Philos Trans R Soc B 2006; 361: 1137–1148.

    Article  Google Scholar 

  16. Stewart JE, Feinle-Bisset C, Keast RSJ . Fatty acid detection during food consumption and digestion: associations with ingestive behavior and obesity. Prog Lipid Res 2011; 50: 225–233.

    Article  CAS  Google Scholar 

  17. Chevrot M, Passilly-Degrace P, Ancel D, Bernard A, Enderli G, Gomes M et al. Obesity interferes with the orosensory detection of long-chain fatty acids in humans. Am J Clin Nutr 2014; 99: 975–983.

    Article  CAS  Google Scholar 

  18. Tucker RM, Edlinger C, Craig BA, Mattes RD . Associations between BMI and fat taste sensitivity in humans. Chem Senses 2014; 39: 349–357.

    Article  CAS  Google Scholar 

  19. Stewart JE, Seimon RV, Otto B, Keast RS, Clifton PM, Feinle-Bisset C . Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men. Am J Clin Nutr 2011; 93: 703–711.

    Article  CAS  Google Scholar 

  20. Keller A, Rohde JF, Raymond K, Heitmann BL . The association between periodontal disease and overweight and obesity: a systematic review. J Periodontol 2015; 20: 1–15.

    Google Scholar 

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Acknowledgements

CV acknowledges her PhD grant from INRA and CNIEL. GF thanks the Burgundy Regional Council for funding. MCM thanks CNIEL for funding the clinical trial. We thank Hélène Brignot for technical assistance. Yvonne Masson is acknowledged for revising the English language. We thank the volunteers and the team of CRNH-RA for their involvement. This work was supported by the Institut National de la Recherche Agronomique (INRA), the Burgundy Region (The Regional Council) and the Centre National Interprofessionnel de l’Economie Laitière (CNIEL).

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Author notes

  1. M-C Michalski and G Feron: These authors contributed equally to this work.

Authors and Affiliations

  1. INRA, UMR 1397, CarMeN Laboratory, Univ Lyon-1, Oullins, France

    C Vors, L Gabert, M Laville, H Vidal & M-C Michalski

  2. INSERM U1060, CarMeN Laboratory, Oullins, France

    C Vors & H Vidal

  3. Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA) and Centre Européen pour la Nutrition et la Santé (CENS), Pierre-Bénite, France

    C Vors, L Gabert, M Laville & M-C Michalski

  4. Laboratoire de Biochimie, Centre Hospitalier Lyon Sud, Pierre-Bénite, France

    J Drai

  5. INRA, UMR 1397, CarMeN Laboratory, Villeurbanne, France

    G Pineau & M-C Michalski

  6. INSA-Lyon, IMBL, Villeurbanne, France

    G Pineau & M-C Michalski

  7. CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, Dijon, France

    E Guichard & G Feron

  8. INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, Dijon, France

    E Guichard & G Feron

  9. Université de Bourgogne, UMR Centre des Sciences du Goût et de l'Alimentation, Dijon, France

    E Guichard & G Feron

Authors
  1. C Vors
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  2. J Drai
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  3. L Gabert
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  4. G Pineau
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  5. M Laville
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  6. H Vidal
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  7. E Guichard
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  8. M-C Michalski
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  9. G Feron
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Corresponding author

Correspondence to M-C Michalski.

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Vors, C., Drai, J., Gabert, L. et al. Salivary composition in obese vs normal-weight subjects: towards a role in postprandial lipid metabolism?. Int J Obes 39, 1425–1428 (2015). https://doi.org/10.1038/ijo.2015.71

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  • DOI: https://doi.org/10.1038/ijo.2015.71

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