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Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case–control study

Genes & Immunity volume 10, pages 586–590 (2009)Cite this article

Abstract

Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [−7400InDel, −6752AT (rs6676671), −3538AT (rs1800890), −1087AG (rs1800896), −597AC (rs1800872)] of the IL-10 5′-flanking region in a hospital-based case–control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 ‘higher producing’ haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma (adjusted P=0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma.

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Acknowledgements

We are grateful to the Deutsche Forschungsgemeinschaft DFG (Graduate College 1034, www.gcpg.de) for supporting this work and the colleagues of the GRK1034 for helpful discussions.

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Author notes

  1. K Reich

    Present address: 5Current address: Dermatologikum Hamburg, Germany,

Authors and Affiliations

  1. Department of Hematology and Oncology, Georg-August University of Goettingen, Goettingen, Germany

    N Schoof, F von Bonin & D Kube

  2. Institute of Medical Biometry and Statistics, University Luebeck, Luebeck, Germany

    I R König & A Ziegler

  3. Department of Dermatology, Georg-August University of Goettingen, Goettingen, Germany

    R Mössner, U Krüger, K Reich, L Böckmann, C Kuschal, K-M Thoms & S Emmert

  4. Department of Dermatology, Ludwig-Maximilians-University of Munich, Munich, Germany,

    C Berking & M Volkenandt

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  1. N Schoof
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  2. F von Bonin
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Correspondence to D Kube.

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Schoof, N., von Bonin, F., König, I. et al. Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case–control study. Genes Immun 10, 586–590 (2009). https://doi.org/10.1038/gene.2009.40

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  • DOI: https://doi.org/10.1038/gene.2009.40

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