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Estimation of size of cord blood inventory based on high-resolution typing of HLAs

Bone Marrow Transplantation volume 49, pages 977–979 (2014)Cite this article

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Abstract

Methods for estimating the cord blood (CB) inventory size required vary according to the ethnic diversity of the HLA, degree of HLA matching and HLA-typing resolution. We estimated the CB inventory size required using 7190 stored CB units (CBU) and 2450 patients who were awaiting or underwent allogeneic hematopoietic stem cell transplantation. With high-resolution typing of HLA-A, B and DRB1, 94.6% of Korean patients could find CBUs in 100 000 CBUs with a 5/6 match, and 95.7% could find CBUs in 5000 CBUs with a 4/6 match. With low-resolution typing of HLA-A and B and high-resolution typing of leukocyte antigen-DRB1, 95% of patients could find CBUs in 50 000 CBUs with a 5/6 match, and 96.7% could find CBUs in 3000 CBUs with a 4/6 match. With additional high-resolution typing for HLA-A and B, which could improve transplantation outcome, the size of the CB inventory would need to increase twofold for Koreans.

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Acknowledgements

EYS and JYH contributed to drafting of the article; SO designed and performed statistical analysis; EYR contributed to acquisition of CB data; JHY contributed to the analysis of patients' HLA data; MHP was the intellectual advisor of HLA allelic distribution and data analysis; MSK and SS contributed to overall conception and designing the study.

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Author notes

  1. E Y Song and J Y Huh: These authors contributed equally to this study as joint first authors.

  2. M S Kang and S Shin: These authors contributed equally to this study as co-corresponding authors.

Authors and Affiliations

  1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea

    E Y Song, J H Yoon, E Y Roh, M H Park & S Shin

  2. Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea

    J Y Huh & M S Kang

  3. Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Korea

    S Y Kim & T G Kim

  4. Department of Biostatistics, Boramae Hospital, Seoul, Korea,

    S Oh

  5. Department of Laboratory Medicine, Boramae Hospital, Seoul, Korea

    J H Yoon, E Y Roh & S Shin

  6. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea

    J H Yoon, E Y Roh & S Shin

  7. CHA Medical Center Cord Blood Bank, Seongnam, Korea

    M S Kang

Authors
  1. E Y Song
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Correspondence to M S Kang or S Shin.

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Supplementary Information accompanies this paper on Bone Marrow Transplantation website

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Song, E., Huh, J., Kim, S. et al. Estimation of size of cord blood inventory based on high-resolution typing of HLAs. Bone Marrow Transplant 49, 977–979 (2014). https://doi.org/10.1038/bmt.2014.76

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  • DOI: https://doi.org/10.1038/bmt.2014.76

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